Prolyl hydroxylase EGLN3

BE0002219ProteinHumansEGLN3

Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4, GPX4 and HIF1A (PubMed:19584355, PubMed:20978507, PubMed:21483450, PubMed:21575608, PubMed:21620138, PubMed:22797300, PubMed:40281343). It is acted on by 7 drugs in DrugBank.

Gene name
EGLN3
UniProtKB entry
Q9H6Z9Swiss-Prot
Cellular location
Nucleus
Residues / weight
239 residues · 27,261 Da
Also known as
1.14.11.- · Egl nine homolog 3 · HIF-PH3 · HIF-prolyl hydroxylase 3 · HPH-1

Resolves to

Protein
UniProtQ9H6Z9UniProt nameEGLN3_HUMAN
Gene
HGNCHGNC:14661NCBI Gene112399GenBank14547150GeneCardsEGLN3
Pharmacology
IUPHAR/GtoPdb2834KEGGhsa:112399
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl hydroxylase EGLN3, how selective are they, and which programs against it are still in active trials?

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