N-acetyl-D-glucosamine kinase

BE0002265ProteinHumansNAGK

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:22692205). It is acted on by 2 drugs in DrugBank.

Gene name
NAGK
UniProtKB entry
Q9UJ70Swiss-Prot
Residues / weight
344 residues · 37,375 Da
Also known as
2.7.1.59 · GlcNAc kinase · Muramyl dipeptide kinase · N-acetyl-D-mannosamine kinase · N-acetylglucosamine kinase

Resolves to

Protein
UniProtQ9UJ70UniProt nameNAGK_HUMAN
Gene
HGNCHGNC:17174NCBI Gene55577GenBank6491737GeneCardsNAGK
Pharmacology
KEGGhsa:55577
Structure
PDB2CH5PDB2CH6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-acetyl-D-glucosamine kinase, how selective are they, and which programs against it are still in active trials?

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