Microsomal glutathione S-transferase 1

BE0002282ProteinHumansMGST1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. It is acted on by 3 drugs in DrugBank.

Gene name
MGST1
UniProtKB entry
P10620Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
155 residues · 17,598 Da
Also known as
2.5.1.18 · GST12 · MGST · Microsomal GST-1 · Microsomal GST-I

Resolves to

Protein
UniProtP10620UniProt nameMGST1_HUMAN
Gene
HGNCHGNC:7061NCBI Gene4257GenBank306808GeneCardsMGST1
Pharmacology
KEGGhsa:4257
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Microsomal glutathione S-transferase 1, how selective are they, and which programs against it are still in active trials?

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