Peptidyl-prolyl cis-trans isomerase B

BE0002332ProteinHumansPPIB

Peptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. It is acted on by 3 drugs in DrugBank.

Gene name
PPIB
UniProtKB entry
P23284Swiss-Prot
Cellular location
Virion
Residues / weight
216 residues · 23,742 Da
Also known as
5.2.1.8 · Cyclophilin B · CYP-S1 · CYPB · PPIase B

Resolves to

Protein
UniProtP23284UniProt namePPIB_HUMAN
Gene
HGNCHGNC:9255NCBI Gene5479GenBank181335GeneCardsPPIB
Pharmacology
KEGGhsa:5479
Structure
PDB1CYNPDB3ICHPDB3ICI
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-prolyl cis-trans isomerase B, how selective are they, and which programs against it are still in active trials?

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