Gamma-aminobutyric acid receptor subunit beta-3

BE0002345ProteinHumansGABRB3

Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:14993607, PubMed:18514161, PubMed:22243422, PubMed:22303015, PubMed:24909990, PubMed:26950270, PubMed:30602789). It is acted on by 8 drugs in DrugBank.

Gene name
GABRB3
UniProtKB entry
P28472Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
473 residues · 54,115 Da
Also known as
GABA(A) receptor subunit beta-3 · GABAAR subunit beta-3

Resolves to

Protein
UniProtP28472UniProt nameGBRB3_HUMAN
Gene
HGNCHGNC:4083NCBI Gene2562GenBank182925GeneCardsGABRB3
Pharmacology
IUPHAR/GtoPdb412KEGGhsa:2562
Structure
PDB4COFPDB5O8FPDB5OJM
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Gamma-aminobutyric acid receptor subunit beta-3, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In