Gamma-aminobutyric acid receptor subunit beta-2

BE0002346ProteinHumansGABRB2

Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:19763268, PubMed:27789573, PubMed:29950725, PubMed:8264558). It is acted on by 13 drugs in DrugBank.

Gene name
GABRB2
UniProtKB entry
P47870Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
512 residues · 59,150 Da
Also known as
GABA(A) receptor subunit beta-2 · GABAAR subunit beta-2

Resolves to

Protein
UniProtP47870UniProt nameGBRB2_HUMAN
Gene
HGNCHGNC:4082NCBI Gene2561GenBank455946GeneCardsGABRB2
Pharmacology
KEGGhsa:2561
Structure
PDB6D6TPDB6D6UPDB6X3S
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit beta-2, how selective are they, and which programs against it are still in active trials?

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