Proteasome subunit beta type-5

BE0002348ProteinHumansPSMB5

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 9 drugs in DrugBank.

Gene name
PSMB5
UniProtKB entry
P28074Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
263 residues · 28,480 Da
Also known as
3.4.25.1 · beta-5 · LMPX · Macropain epsilon chain · MB1

Resolves to

Protein
UniProtP28074UniProt namePSB5_HUMAN
Gene
HGNCHGNC:9542NCBI Gene5693GenBank558526GeneCardsPSMB5
Pharmacology
IUPHAR/GtoPdb2406KEGGhsa:5693
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteasome subunit beta type-5, how selective are they, and which programs against it are still in active trials?

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