Bortezomib D-mannitol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Velcade
Generic Name
Bortezomib D-mannitol
DrugBank Accession Number
DB16741
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 530.39
Monoisotopic: 530.254794
Chemical Formula
C25H35BN4O8
Synonyms
  • Bortezomib D-mannitol ester
  • Bortezomib D-mannitol symmetrical ester
  • Bortezomib mannitol boronic ester

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AmbroxolThe risk or severity of methemoglobinemia can be increased when Bortezomib D-mannitol is combined with Ambroxol.
ArticaineThe risk or severity of methemoglobinemia can be increased when Bortezomib D-mannitol is combined with Articaine.
BenzocaineThe risk or severity of methemoglobinemia can be increased when Bortezomib D-mannitol is combined with Benzocaine.
Benzyl alcoholThe risk or severity of methemoglobinemia can be increased when Bortezomib D-mannitol is combined with Benzyl alcohol.
BupivacaineThe risk or severity of methemoglobinemia can be increased when Bortezomib D-mannitol is combined with Bupivacaine.
Food Interactions
Not Available

Products

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Active Moieties
NameKindUNIICASInChI Key
Bortezomibprodrug69G8BD63PP179324-69-7GXJABQQUPOEUTA-RDJZCZTQSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Act BortezomibPowder, for solution3.5 mg / vialIntravenous; SubcutaneousTEVA Canada Limited2015-11-17Not applicableCanada flag
BortezomibPowder, for solution3.5 mg / vialIntravenous; SubcutaneousApotex Corporation2019-03-25Not applicableCanada flag
Bortezomib for InjectionPowder, for solution1 mg / vialIntravenous; SubcutaneousPfizer Canada UlcNot applicableNot applicableCanada flag
Bortezomib for InjectionPowder, for solution3.5 mg / vialIntravenous; SubcutaneousGeneric Medical Partners IncNot applicableNot applicableCanada flag
Bortezomib for InjectionPowder, for solution2.5 mg / vialIntravenous; SubcutaneousPfizer Canada Ulc2020-06-23Not applicableCanada flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
PMS-bortezomibPowder, for solution3.5 mg / vialIntravenous; SubcutaneousPharmascience Inc2018-06-05Not applicableCanada flag
Taro-bortezomibPowder, for solution1 mg / vialIntravenous; SubcutaneousTaro Pharmaceuticals, Inc.Not applicableNot applicableCanada flag
Taro-bortezomibPowder, for solution2.5 mg / vialIntravenous; SubcutaneousTaro Pharmaceuticals, Inc.2022-07-18Not applicableCanada flag
Taro-bortezomibPowder, for solution3.5 mg / vialIntravenous; SubcutaneousTaro Pharmaceuticals, Inc.2021-04-12Not applicableCanada flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
P2AWN9VSQ6
CAS number
444576-08-3
InChI Key
QDMRNLRJDHCHLB-DNNBANOASA-N
InChI
InChI=1S/C25H35BN4O8/c1-15(2)10-21(26-37-22(19(33)13-31)23(38-26)20(34)14-32)30-24(35)17(11-16-6-4-3-5-7-16)29-25(36)18-12-27-8-9-28-18/h3-9,12,15,17,19-23,31-34H,10-11,13-14H2,1-2H3,(H,29,36)(H,30,35)/t17-,19+,20+,21-,22+,23+/m0/s1
IUPAC Name
(2S)-N-[(1R)-1-[(4R,5R)-4,5-bis[(1R)-1,2-dihydroxyethyl]-1,3,2-dioxaborolan-2-yl]-3-methylbutyl]-3-phenyl-2-[(pyrazin-2-yl)formamido]propanamide
SMILES
[H][C@@]1(OB(O[C@]1([H])[C@H](O)CO)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)[C@H](O)CO

References

General References
Not Available
ChemSpider
64854571

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionKidney Transplantation1
4CompletedTreatmentHLA Sensitization1
4RecruitingTreatmentMultiple Myeloma (MM)1
4TerminatedTreatmentMultiple Myeloma (MM)1
4Unknown StatusTreatmentMultiple Myeloma (MM)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Powder, for solutionIntravenous1 mg / vial
Powder, for solutionIntravenous; Subcutaneous1 mg / vial
Powder, for solutionIntravenous; Subcutaneous2.5 mg / vial
Powder, for solutionIntravenous; Subcutaneous3 mg / vial
Powder, for solutionIntravenous; Subcutaneous3.5 mg / vial
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.639 mg/mLALOGPS
logP-0.21ALOGPS
logP0.12Chemaxon
logS-2.9ALOGPS
pKa (Strongest Acidic)12.75Chemaxon
pKa (Strongest Basic)-0.59Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count10Chemaxon
Hydrogen Donor Count6Chemaxon
Polar Surface Area183.36 Å2Chemaxon
Rotatable Bond Count13Chemaxon
Refractivity130.22 m3·mol-1Chemaxon
Polarizability55.93 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-1000090000-bd2eef1b2d15a48b56fa
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0211290000-95b08b120080fe6534dc
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-01q9-3463790000-14cf1cacf4661cb49629
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-06dj-3817910000-6cecd6795c35b2b61b34
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-070x-9770320000-44fff6e264100566c131
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0pbc-8924320000-d7dcc4fd84c829dda035
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at November 27, 2021 17:13 / Updated at March 18, 2024 16:48