3',5'-cyclic-AMP phosphodiesterase 4C

BE0002353ProteinHumansPDE4C

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. It is acted on by 6 drugs in DrugBank.

Gene name
PDE4C
UniProtKB entry
Q08493Swiss-Prot
Cellular location
Cell projection, cilium
Residues / weight
712 residues · 79,901 Da
Also known as
3.1.4.53 · cAMP-specific phosphodiesterase 4C · DPDE1 · PDE21

Resolves to

Protein
UniProtQ08493UniProt namePDE4C_HUMAN
Gene
HGNCHGNC:8782NCBI Gene5143GenBank727223GeneCardsPDE4C
Pharmacology
IUPHAR/GtoPdb1302KEGGhsa:5143
Structure
PDB2QYM
Drugs

What you can answer from here — as of September 03, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 3',5'-cyclic-AMP phosphodiesterase 4C, how selective are they, and which programs against it are still in active trials?

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