DB00651ApprovedWithdrawnSmall molecule
Dyphylline is a theophylline derivative used to treat asthma, bronchospasm, and COPD. Dyphylline is a theophylline derivative with broncho- and vasodilator properties.
- Mechanism
- Curator reviewed
The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.
- Primary indication
- For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.Curator reviewed · 8 structured indications
- Formula / weight
- C10H14N4O4 · 254.2426 g/mol (avg)
- First approval
- Canada, 1962 · United States, 1976
- Also known as
- dihydroxypropyltheophylline · Diprophylline
Resolves to
Structure
InChIKey
KSCFJBIXMNOVSH-UHFFFAOYSA-NSMILESCN1C2=C(N(CC(O)CO)C=N2)C(=O)N(C)C1=OWhat you can answer from here — as of September 23, 2026
9Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Dyphylline, and which of those have an active Phase 3 trial?
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