Voltage-dependent L-type calcium channel subunit beta-2

BE0002354ProteinHumansCACNB2

Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). It is acted on by 10 drugs in DrugBank.

Gene name
CACNB2
UniProtKB entry
Q08289Swiss-Prot
Cellular location
Cell membrane, sarcolemma
Residues / weight
660 residues · 73,580 Da
Also known as
CAB2 · CACNLB2 · Calcium channel voltage-dependent subunit beta 2 · Lambert-Eaton myasthenic syndrome antigen B · MYSB

Resolves to

Protein
UniProtQ08289UniProt nameCACB2_HUMAN
Gene
HGNCHGNC:1402NCBI Gene783GenBank300417GeneCardsCACNB2
Pharmacology
KEGGhsa:783
Structure
PDB8HLPPDB8HMAPDB8HMB
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent L-type calcium channel subunit beta-2, how selective are they, and which programs against it are still in active trials?

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