Nilvadipine

DB06712ApprovedSmall molecule

Nilvadipine is a calcium channel blocker used to manage arterial hypertension. A drug used to treat high blood pressure.

Mechanism: Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Curator reviewed
Primary indication: For the management of vasospastic angina, chronic stable angina and hypertension.Curator reviewed · 1 structured indication
Formula / weight: C₁₉H₁₉N₃O₆ · 385.3707 g/mol (avg)
Code names: CL 287,389 · FK 235 · FR-34235 · SK&F 102,362

Resolves to

Compound

UNII0214FUT37JCAS75530-68-6ChEMBLCHEMBL517427ChEBI31911PubChem4494KEGGD01908

Clinical / RWD

RxNorm53692ATCC08CA10PharmGKBPA165958385

Structure

InChIKeyFAIIFDPAEUKBEP-UHFFFAOYSA-NSMILESCOC(=O)C1=C(NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C)C#N

Targets

Q13936CACNA1CP54289CACNA2D1Q08289CACNB2Q01668CACNA1DQ13698CACNA1SQ8IZS8CACNA2D3O95180CACNA1HQ9P0X4CACNA1I

What you can answer from here — as of August 25, 2026

10Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,807Drug interactionsStructured to mechanism, not free text

2Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

5ContraindicationsEach with its own population and attribute set

9Marketed productsAcross 3 countries and 2 labellers

1ATC codeIncluding every combination product, plus 30 drug categories

30+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nilvadipine, and which of those have an active Phase 3 trial?

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