Protein deacetylase HDAC6

BE0002368ProteinHumansHDAC6

Deacetylates a wide range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:30770470, PubMed:38534334, PubMed:39567688). It is acted on by 12 drugs in DrugBank.

Gene name
HDAC6
UniProtKB entry
Q9UBN7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,215 residues · 131,418 Da
Also known as
3.5.1.- · E3 ubiquitin-protein ligase HDAC6 · KIAA0901 · Tubulin-lysine deacetylase HDAC6

Resolves to

Protein
UniProtQ9UBN7UniProt nameHDAC6_HUMAN
Gene
HGNCHGNC:14064NCBI Gene10013GenBank4754911GeneCardsHDAC6
Pharmacology
IUPHAR/GtoPdb2618KEGGhsa:10013
Structure
PDB3C5KPDB3GV4PDB3PHD
Drugs

What you can answer from here — as of June 26, 2025

12DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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29GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein deacetylase HDAC6, how selective are they, and which programs against it are still in active trials?

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