Martinostat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Martinostat
DrugBank Accession Number
DB14979
Background

Martinostat is under investigation in clinical trial NCT03721211 (Imaging With [11C]Martinostat in Breast Cancer).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 354.494
Monoisotopic: 354.230728214
Chemical Formula
C22H30N2O2
Synonyms
Not Available

Pharmacology

Indication

Not Available

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
8JJC99KHGL
CAS number
1629052-58-9
InChI Key
WNIDBXBLQFPAJA-VOTSOKGWSA-N
InChI
InChI=1S/C22H30N2O2/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22/h2-7,18-20,26H,8-15H2,1H3,(H,23,25)/b7-6+
IUPAC Name
(2E)-3-[4-({[(adamantan-1-yl)methyl](methyl)amino}methyl)phenyl]-N-hydroxyprop-2-enamide
SMILES
CN(CC1=CC=C(\C=C\C(=O)NO)C=C1)CC12CC3CC(CC(C3)C1)C2

References

General References
Not Available
ChemSpider
34987952
BindingDB
323709
Wikipedia
Martinostat

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1WithdrawnDiagnosticBreast Cancer1
Not AvailableNot Yet RecruitingDiagnosticDiabetes / Heart Failure With Normal Ejection Fraction / Left Ventricular Hypertrophy / Valve Stenoses, Aortic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00127 mg/mLALOGPS
logP4.17ALOGPS
logP3ChemAxon
logS-5.4ALOGPS
pKa (Strongest Acidic)9.23ChemAxon
pKa (Strongest Basic)9.87ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area52.57 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity105.37 m3·mol-1ChemAxon
Polarizability40.91 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on May 20, 2019 14:39 / Updated on June 12, 2020 16:53