Protein farnesyltransferase subunit beta

BE0002372ProteinHumansFNTB

Essential subunit of the farnesyltransferase complex. It is acted on by 15 drugs in DrugBank.

Gene name
FNTB
UniProtKB entry
P49356Swiss-Prot
Residues / weight
437 residues · 48,773 Da
Also known as
2.5.1.58 · CAAX farnesyltransferase subunit beta · FTase-beta · Ras proteins prenyltransferase subunit beta

Resolves to

Protein
UniProtP49356UniProt nameFNTB_HUMAN
Gene
HGNCHGNC:3785NCBI Gene2342GeneCardsFNTB
Pharmacology
IUPHAR/GtoPdb2826KEGGhsa:2342
Structure
PDB1JCQPDB1LD7PDB1LD8
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein farnesyltransferase subunit beta, how selective are they, and which programs against it are still in active trials?

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