Chloride channel protein ClC-Ka

BE0002376ProteinHumansCLCNKA

Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (PubMed:11734858, PubMed:12111250). It is acted on by 2 drugs in DrugBank.

Gene name
CLCNKA
UniProtKB entry
P51800Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
687 residues · 75,284 Da
Also known as
Chloride channel Ka · ClC-K1

Resolves to

Protein
UniProtP51800UniProt nameCLCKA_HUMAN
Gene
HGNCHGNC:2026NCBI Gene1187GeneCardsCLCNKA
Pharmacology
IUPHAR/GtoPdb700KEGGhsa:1187
Structure
PDB2PFI
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Chloride channel protein ClC-Ka, and which indications are they being tested in?

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