DNA-dependent protein kinase catalytic subunit

BE0002385ProteinHumansPRKDC

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). It is acted on by 9 drugs in DrugBank.

Gene name
PRKDC
UniProtKB entry
P78527Swiss-Prot
Cellular location
Nucleus
Residues / weight
4,128 residues · 469,084 Da
Also known as
2.7.11.1 · DNA-PK catalytic subunit · DNA-PKcs · DNPK1 · HYRC

Resolves to

Protein
UniProtP78527UniProt namePRKDC_HUMAN
Gene
HGNCHGNC:9413NCBI Gene5591GeneCardsPRKDC
Pharmacology
IUPHAR/GtoPdb2800KEGGhsa:5591
Structure
PDB5LUQPDB5W1RPDB5Y3R
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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83+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-dependent protein kinase catalytic subunit, how selective are they, and which programs against it are still in active trials?

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