DNA-dependent protein kinase catalytic subunit
Details
- Name
- DNA-dependent protein kinase catalytic subunit
- Kind
- protein
- Synonyms
- 2.7.11.1
- DNA-PK catalytic subunit
- DNA-PKcs
- DNPK1
- HYRC
- HYRC1
- p460
- Gene Name
- PRKDC
- UniProtKB Entry
- P78527Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004685|DNA-dependent protein kinase catalytic subunit MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
- Number of residues
- 4128
- Molecular Weight
- 469084.155
- Theoretical pI
- 7.12
- GO Classification
- FunctionsATP binding / DNA-dependent protein kinase activity / double-stranded DNA binding / protein kinase activity / protein serine/threonine kinase activityProcessesB cell lineage commitment / brain development / cellular response to insulin stimulus / double-strand break repair / double-strand break repair via nonhomologous end joining / ectopic germ cell programmed cell death / heart development / immunoglobulin V(D)J recombination / innate immune response / intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of apoptotic process / negative regulation of protein phosphorylation / peptidyl-serine phosphorylation / positive regulation of apoptotic process / pro-B cell differentiation / protein destabilization / regulation of circadian rhythm / regulation of smooth muscle cell proliferation / response to gamma radiation / rhythmic process / somitogenesis / T cell differentiation in thymus / T cell lineage commitment / T cell receptor V(D)J recombination / telomere maintenanceComponentscytosol / DNA-dependent protein kinase-DNA ligase 4 complex / membrane / nonhomologous end joining complex / nucleolus / nucleoplasm
- General Function
- Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:33854234, PubMed:34352203). Must be bound to DNA to express its catalytic properties (PubMed:11955432). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (PubMed:11955432). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326, PubMed:33854234). Act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion (By similarity). Also involved in modulation of transcription (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). As part of the DNA-PK complex, involved in the early steps of ribosome assembly by promoting the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome (PubMed:32103174). Binding to U3 small nucleolar RNA, recruits PRKDC and XRCC5/Ku86 to the small-subunit processome (PubMed:32103174). Recognizes the substrate consensus sequence [ST]-Q (PubMed:11955432, PubMed:12649176, PubMed:14734805, PubMed:15574326). Phosphorylates 'Ser-139' of histone variant H2AX, thereby regulating DNA damage response mechanism (PubMed:14627815, PubMed:16046194). Phosphorylates ASF1A, DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, FH, SRF, NHEJ1/XLF, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2 (PubMed:10026262, PubMed:10467406, PubMed:11889123, PubMed:12509254, PubMed:14599745, PubMed:14612514, PubMed:14704337, PubMed:15177042, PubMed:1597196, PubMed:16397295, PubMed:18644470, PubMed:2247066, PubMed:2507541, PubMed:26237645, PubMed:26666690, PubMed:28712728, PubMed:29478807, PubMed:30247612, PubMed:8407951, PubMed:8464713, PubMed:9139719, PubMed:9362500). Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA (PubMed:9679063). Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D (PubMed:9363941). Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect mechanism (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Also regulates the cGAS-STING pathway by catalyzing phosphorylation of CGAS, thereby impairing CGAS oligomerization and activation (PubMed:33273464). Also regulates the cGAS-STING pathway by mediating phosphorylation of PARP1 (PubMed:35460603)
- Specific Function
- Atp binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0016774|DNA-dependent protein kinase catalytic subunit (PRKDC) ATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCCCTGCTGCGGCTGCAGGAGACCTTGTCC GCTGCGGACCGCTGCGGTGCTGCCCTGGCCGGTCATCAACTGATCCGCGGCCTGGGGCAG GAATGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCC AGAGATTTCGGTTTGCTTGTATTTGTCCGGAAGTCACTCAACAGTATTGAATTTCGTGAA TGTAGAGAAGAAATCCTAAAGTTTTTATGTATTTTCTTAGAAAAAATGGGCCAGAAGATC GCACCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCT GCTAAATGTAAAATTCCAGCCCTGGACCTTCTTATTAAGTTACTTCAGACTTTTAGAAGT TCTAGACTCATGGATGAATTTAAAATTGGAGAATTATTTAGTAAATTCTATGGAGAACTT GCATTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTA TTGGGTGAAGTTCATCCTAGTGAGATGATAAATAATGCAGAAAACCTGTTCCGCGCTTTT CTGGGTGAACTTAAGACCCAGATGACATCAGCAGTAAGAGAGCCCAAACTACCTGTTCTG GCAGGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAA GATCCCCAGACTTCAAGGGAGATTTTTAATTTTGTACTAAAGGCAATTCGTCCTCAGATT GATCTGAAGAGATATGCTGTGCCCTCAGCTGGCTTGCGCCTATTTGCCCTGCATGCATCT CAGTTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGG TGTGCCCACACAAATGTAGAATTGAAAAAAGCTGCACTTTCAGCCCTGGAATCCTTTCTG AAACAGGTTTCTAATATGGTGGCGAAAAATGCAGAAATGCATAAAAATAAACTGCAGTAC TTTATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCT ATTGCTATCCGTGGATATGGACTTTTTGCAGGACCGTGCAAGGTTATAAACGCAAAAGAT GTTGACTTCATGTACGTTGAGCTCATTCAGCGCTGCAAGCAGATGTTCCTCACCCAGACA GACACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTC TTGCTGTACCTTGACACAGTTCCTGAGGTGTATACTCCAGTTCTGGAGCACCTCGTGGTG ATGCAGATAGACAGTTTCCCACAGTACAGTCCAAAAATGCAGCTGGTGTGTTGCAGAGCC ATAGTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGT ACTGTGGTGCATCAGGGTTTAATCAGAATATGTTCTAAACCAGTGGTCCTTCCAAAGGGC CCTGAGTCTGAATCTGAAGACCACCGTGCTTCAGGGGAAGTCAGAACTGGCAAATGGAAG GTGCCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATG ATGGATTCTATTTTAGCAGATGAAGCATTTTTCTCTGTGAATTCCTCCAGTGAAAGTCTG AATCATTTACTTTATGATGAATTTGTAAAATCCGTTTTGAAGATTGTTGAGAAATTGGAT CTTACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTT TGGATGATCCCAACTTCAGATCCAGCGGCTAACTTGCATCCAGCTAAACCTAAAGATTTT TCGGCTTTCATTAACCTGGTGGAATTTTGCAGAGAGATTCTCCCTGAGAAACAAGCAGAA TTTTTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTG CCCCTCATCAGTGGTTTCTACAAATTGCTTTCTATTACAGTAAGAAATGCCAAGAAAATA AAATATTTCGAGGGAGTTAGTCCAAAGAGTCTGAAACACTCTCCTGAAGACCCAGAAAAG TATTCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAG TACAAAGATGAACTTTTGGCCTCTTGTTTGACCTTTCTTCTGTCCTTGCCACACAACATC ATTGAACTCGATGTTAGAGCCTACGTTCCTGCACTGCAGATGGCTTTCAAACTGGGCCTG AGCTATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATT GACAGACATGTAATGCAGCCTTATTACAAAGACATTCTCCCCTGCCTGGATGGATACCTG AAGACTTCAGCCTTGTCAGATGAGACCAAGAATAACTGGGAAGTGTCAGCTCTTTCTCGG GCTGCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTT TCATCAAACGAAGCAATATCCTTAGAAGAAATAAGAATTAGAGTAGTACAAATGCTTGGA TCTCTAGGAGGACAAATAAACAAAAATCTTCTGACAGTCACGTCCTCAGATGAGATGATG AAGAGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAG ATGAAACCTGTCATTTTCCTGGATGTGTTCCTGCCTCGAGTCACAGAATTAGCGCTCACA GCCAGTGACAGACAAACTAAAGTTGCAGCCTGTGAACTTTTACATAGCATGGTTATGTTT ATGTTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAG CTCTATAAGCGGACGTTTCCTGTGCTGCTTCGACTTGCGTGTGATGTTGATCAGGTGACA AGGCAACTGTATGAGCCACTAGTTATGCAGCTGATTCACTGGTTCACTAACAACAAGAAA TTTGAAAGTCAGGATACTGTTGCCTTACTAGAAGCTATATTGGATGGAATTGTGGACCCT GTTGACAGTACTTTAAGAGATTTTTGTGGTCGGTGTATTCGAGAATTCCTTAAATGGTCC ATTAAGCAAATAACACCACAGCAGCAGGAGAAGAGTCCAGTAAACACCAAATCGCTTTTC AAGCGACTTTATAGCCTTGCGCTTCACCCCAATGCTTTCAAGAGGCTGGGAGCATCACTT GCCTTTAATAATATCTACAGGGAATTCAGGGAAGAAGAGTCTCTGGTGGAACAGTTTGTG TTTGAAGCCTTGGTGATATACATGGAGAGTCTGGCCTTAGCACATGCAGATGAGAAGTCC TTAGGTACAATTCAACAGTGTTGTGATGCCATTGATCACCTATGCCGCATCATTGAAAAG AAGCATGTTTCTTTAAATAAAGCAAAGAAACGACGTTTGCCGCGAGGATTTCCACCTTCC GCATCATTGTGTTTATTGGATCTGGTCAAGTGGCTTTTAGCTCATTGTGGGAGGCCCCAG ACAGAATGTCGACACAAATCCATTGAACTCTTTTATAAATTCGTTCCTTTATTGCCAGGC AACAGATCCCCTAATTTGTGGCTGAAAGATGTTCTCAAGGAAGAAGGTGTCTCTTTTCTC ATCAACACCTTTGAGGGGGGTGGCTGTGGCCAGCCCTCGGGCATCCTGGCCCAGCCCACC CTCTTGTACCTTCGGGGGCCATTCAGCCTGCAGGCCACGCTATGCTGGCTGGACCTGCTC CTGGCCGCGTTGGAGTGCTACAACACGTTCATTGGCGAGAGAACTGTAGGAGCGCTCCAG GTCCTAGGTACTGAAGCCCAGTCTTCACTTTTGAAAGCAGTGGCTTTCTTCTTAGAAAGC ATTGCCATGCATGACATTATAGCAGCAGAAAAGTGCTTTGGCACTGGGGCAGCAGGTAAC AGAACAAGCCCACAAGAGGGAGAAAGGTACAACTACAGCAAATGCACCGTTGTGGTCCGG ATTATGGAGTTTACCACGACTCTGCTAAACACCTCCCCGGAAGGATGGAAGCTCCTGAAG AAGGACTTGTGTAATACACACCTGATGAGAGTCCTGGTGCAGACGCTGTGTGAGCCCGCA AGCATAGGTTTCAACATCGGAGACGTCCAGGTTATGGCTCATCTTCCTGATGTTTGTGTG AATCTGATGAAAGCTCTAAAGATGTCCCCATACAAAGATATCCTAGAGACCCATCTGAGA GAGAAAATAACAGCACAGAGCATTGAGGAGCTTTGTGCCGTCAACTTGTATGGCCCTGAC GCGCAAGTGGACAGGAGCAGGCTGGCTGCTGTTGTGTCTGCCTGTAAACAGCTTCACAGA GCTGGGCTTCTGCATAATATATTACCGTCTCAGTCCACAGATTTGCATCATTCTGTTGGC ACAGAACTTCTTTCCCTGGTTTATAAAGGCATTGCCCCTGGAGATGAGAGACAGTGTCTG CCTTCTCTAGACCTCAGTTGTAAGCAGCTGGCCAGCGGACTTCTGGAGTTAGCCTTTGCT TTTGGAGGACTGTGTGAGCGCCTTGTGAGTCTTCTCCTGAACCCAGCGGTGCTGTCCACG GCGTCCTTGGGCAGCTCACAGGGCAGCGTCATCCACTTCTCCCATGGGGAGTATTTCTAT AGCTTGTTCTCAGAAACGATCAACACGGAATTATTGAAAAATCTGGATCTTGCTGTATTG GAGCTCATGCAGTCTTCAGTGGATAATACCAAAATGGTGAGTGCCGTTTTGAACGGCATG TTAGACCAGAGCTTCAGGGAGCGAGCAAACCAGAAACACCAAGGACTGAAACTTGCGACT ACAATTCTGCAACACTGGAAGAAGTGTGATTCATGGTGGGCCAAAGATTCCCCTCTCGAA ACTAAAATGGCAGTGCTGGCCTTACTGGCAAAAATTTTACAGATTGATTCATCTGTATCT TTTAATACAAGTCATGGTTCATTCCCTGAAGTCTTTACAACATATATTAGTCTACTTGCT GACACAAAGCTGGATCTACATTTAAAGGGCCAAGCTGTCACTCTTCTTCCATTCTTCACC AGCCTCACTGGAGGCAGTCTGGAGGAACTTAGACGTGTTCTGGAGCAGCTCATCGTTGCT CACTTCCCCATGCAGTCCAGGGAATTTCCTCCAGGAACTCCGCGGTTCAATAATTATGTG GACTGCATGAAAAAGTTTCTAGATGCATTGGAATTATCTCAAAGCCCTATGTTGTTGGAA TTGATGACAGAAGTTCTTTGTCGGGAACAGCAGCATGTCATGGAAGAATTATTTCAATCC AGTTTCAGGAGGATTGCCAGAAGGGGTTCATGTGTCACACAAGTAGGCCTTCTGGAAAGC GTGTATGAAATGTTCAGGAAGGATGACCCCCGCCTAAGTTTCACACGCCAGTCCTTTGTG GACCGCTCCCTCCTCACTCTGCTGTGGCACTGTAGCCTGGATGCTTTGAGAGAATTCTTC AGCACAATTGTGGTGGATGCCATTGATGTGTTGAAGTCCAGGTTTACAAAGCTAAATGAA TCTACCTTTGATACTCAAATCACCAAGAAGATGGGCTACTATAAGATTCTAGACGTGATG TATTCTCGCCTTCCCAAAGATGATGTTCATGCTAAGGAATCAAAAATTAATCAAGTTTTC CATGGCTCGTGTATTACAGAAGGAAATGAACTTACAAAGACATTGATTAAATTGTGCTAC GATGCATTTACAGAGAACATGGCAGGAGAGAATCAGCTGCTGGAGAGGAGAAGACTTTAC CATTGTGCAGCATACAACTGCGCCATATCTGTCATCTGCTGTGTCTTCAATGAGTTAAAA TTTTACCAAGGTTTTCTGTTTAGTGAAAAACCAGAAAAGAACTTGCTTATTTTTGAAAAT CTGATCGACCTGAAGCGCCGCTATAATTTTCCTGTAGAAGTTGAGGTTCCTATGGAAAGA AAGAAAAAGTACATTGAAATTAGGAAAGAAGCCAGAGAAGCAGCAAATGGGGATTCAGAT GGTCCTTCCTATATGTCTTCCCTGTCATATTTGGCAGACAGTACCCTGAGTGAGGAAATG AGTCAATTTGATTTCTCAACCGGAGTTCAGAGCTATTCATACAGCTCCCAAGACCCTAGA CCTGCCACTGGTCGTTTTCGGAGACGGGAGCAGCGGGACCCCACGGTGCATGATGATGTG CTGGAGCTGGAGATGGACGAGCTCAATCGGCATGAGTGCATGGCGCCCCTGACGGCCCTG GTCAAGCACATGCACAGAAGCCTGGGCCCGCCTCAAGGAGAAGAGGATTCAGTGCCAAGA GATCTTCCTTCTTGGATGAAATTCCTCCATGGCAAACTGGGAAATCCAATAGTACCATTA AATATCCGTCTCTTCTTAGCCAAGCTTGTTATTAATACAGAAGAGGTCTTTCGCCCTTAC GCGAAGCACTGGCTTAGCCCCTTGCTGCAGCTGGCTGCTTCTGAAAACAATGGAGGAGAA GGAATTCACTACATGGTGGTTGAGATAGTGGCCACTATTCTTTCATGGACAGGCTTGGCC ACTCCAACAGGGGTCCCTAAAGATGAAGTGTTAGCAAATCGATTGCTTAATTTCCTAATG AAACATGTCTTTCATCCAAAAAGAGCTGTGTTTAGACACAACCTTGAAATTATAAAGACC CTTGTCGAGTGCTGGAAGGATTGTTTATCCATCCCTTATAGGTTAATATTTGAAAAGTTT TCCGGTAAAGATCCTAATTCTAAAGACAACTCAGTAGGGATTCAATTGCTAGGCATCGTG ATGGCCAATGACCTGCCTCCCTATGACCCACAGTGTGGCATCCAGAGTAGCGAATACTTC CAGGCTTTGGTGAATAATATGTCCTTTGTAAGATATAAAGAAGTGTATGCCGCTGCAGCA GAAGTTCTAGGACTTATACTTCGATATGTTATGGAGAGAAAAAACATACTGGAGGAGTCT CTGTGTGAACTGGTTGCGAAACAATTGAAGCAACATCAGAATACTATGGAGGACAAGTTT ATTGTGTGCTTGAACAAAGTGACCAAGAGCTTCCCTCCTCTTGCAGACAGGTTCATGAAT GCTGTGTTCTTTCTGCTGCCAAAATTTCATGGAGTGTTGAAAACACTCTGTCTGGAGGTG GTACTTTGTCGTGTGGAGGGAATGACAGAGCTGTACTTCCAGTTAAAGAGCAAGGACTTC GTTCAAGTCATGAGACATAGAGATGATGAAAGACAAAAAGTATGTTTGGACATAATTTAT AAGATGATGCCAAAGTTAAAACCAGTAGAACTCCGAGAACTTCTGAACCCCGTTGTGGAA TTCGTTTCCCATCCTTCTACAACATGTAGGGAACAAATGTATAATATTCTCATGTGGATT CATGATAATTACAGAGATCCAGAAAGTGAGACAGATAATGACTCCCAGGAAATATTTAAG TTGGCAAAAGATGTGCTGATTCAAGGATTGATCGATGAGAACCCTGGACTTCAATTAATT ATTCGAAATTTCTGGAGCCATGAAACTAGGTTACCTTCAAATACCTTGGACCGGTTGCTG GCACTAAATTCCTTATATTCTCCTAAGATAGAAGTGCACTTTTTAAGTTTAGCAACAAAT TTTCTGCTCGAAATGACCAGCATGAGCCCAGATTATCCAAACCCCATGTTCGAGCATCCT CTGTCAGAATGCGAATTTCAGGAATATACCATTGATTCTGATTGGCGTTTCCGAAGTACT GTTCTCACTCCGATGTTTGTGGAGACCCAGGCCTCCCAGGGCACTCTCCAGACCCGTACC CAGGAAGGGTCCCTCTCAGCTCGCTGGCCAGTGGCAGGGCAGATAAGGGCCACCCAGCAG CAGCATGACTTCACACTGACACAGACTGCAGATGGAAGAAGCTCATTTGATTGGCTGACC GGGAGCAGCACTGACCCGCTGGTCGACCACACCAGTCCCTCATCTGACTCCTTGCTGTTT GCCCACAAGAGGAGTGAAAGGTTACAGAGAGCACCCTTGAAGTCAGTGGGGCCTGATTTT GGGAAAAAAAGGCTGGGCCTTCCAGGGGACGAGGTGGATAACAAAGTGAAAGGTGCGGCC GGCCGGACGGACCTACTACGACTGCGCAGACGGTTTATGAGGGACCAGGAGAAGCTCAGT TTGATGTATGCCAGAAAAGGCGTTGCTGAGCAAAAACGAGAGAAGGAAATCAAGAGTGAG TTAAAAATGAAGCAGGATGCCCAGGTCGTTCTGTACAGAAGCTACCGGCACGGAGACCTT CCTGACATTCAGATCAAGCACAGCAGCCTCATCACCCCGTTACAGGCCGTGGCCCAGAGG GACCCAATAATTGCAAAACAGCTCTTTAGCAGCTTGTTTTCTGGAATTTTGAAAGAGATG GATAAATTTAAGACACTGTCTGAAAAAAACAACATCACTCAAAAGTTGCTTCAAGACTTC AATCGTTTTCTTAATACCACCTTCTCTTTCTTTCCACCCTTTGTCTCTTGTATTCAGGAC ATTAGCTGTCAGCACGCAGCCCTGCTGAGCCTCGACCCAGCGGCTGTTAGCGCTGGTTGC CTGGCCAGCCTACAGCAGCCCGTGGGCATCCGCCTGCTAGAGGAGGCTCTGCTCCGCCTG CTGCCTGCTGAGCTGCCTGCCAAGCGAGTCCGTGGGAAGGCCCGCCTCCCTCCTGATGTC CTCAGATGGGTGGAGCTTGCTAAGCTGTATAGATCAATTGGAGAATACGACGTCCTCCGT GGGATTTTTACCAGTGAGATAGGAACAAAGCAAATCACTCAGAGTGCATTATTAGCAGAA GCCAGAAGTGATTATTCTGAAGCTGCTAAGCAGTATGATGAGGCTCTCAATAAACAAGAC TGGGTAGATGGTGAGCCCACAGAAGCCGAGAAGGATTTTTGGGAACTTGCATCCCTTGAC TGTTACAACCACCTTGCTGAGTGGAAATCACTTGAATACTGTTCTACAGCCAGTATAGAC AGTGAGAACCCCCCAGACCTAAATAAAATCTGGAGTGAACCATTTTATCAGGAAACATAT CTACCTTACATGATCCGCAGCAAGCTGAAGCTGCTGCTCCAGGGAGAGGCTGACCAGTCC CTGCTGACATTTATTGACAAAGCTATGCACGGGGAGCTCCAGAAGGCGATTCTAGAGCTT CATTACAGTCAAGAGCTGAGTCTGCTTTACCTCCTGCAAGATGATGTTGACAGAGCCAAA TATTACATTCAAAATGGCATTCAGAGTTTTATGCAGAATTATTCTAGTATTGATGTCCTC TTACACCAAAGTAGACTCACCAAATTGCAGTCTGTACAGGCTTTAACAGAAATTCAGGAG TTCATCAGCTTTATAAGCAAACAAGGCAATTTATCATCTCAAGTTCCCCTTAAGAGACTT CTGAACACCTGGACAAACAGATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGAT GACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCTTACCCCTCTT CCAGAAGATAATAGTATGAATGTGGATCAAGATGGAGACCCCAGTGACAGGATGGAAGTG CAAGAGCAGGAAGAAGATATCAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATG AAGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAAACTACTGAAG GAGCTGCATAAAGAGTCAAAAACCAGAGACGATTGGCTGGTGAGCTGGGTGCAGAGCTAC TGCCGCCTGAGCCACTGCCGGAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTG CTGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAGCAAAAATATT CTGGCTTTCCGTGACCAGAACATTCTCTTGGGTACAACTTACAGGATCATAGCGAATGCT CTCAGCAGTGAGCCAGCCTGCCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTA GAGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCTGTACCAGAGA GCATTCCAGCACCTCTCTGAGGCTGTGCAGGCGGCTGAGGAGGAGGCCCAGCCTCCCTCC TGGAGCTGTGGGCCTGCAGCTGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGT GACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGCAGAACTGCAG GCGTATCCAGCACTTGTGGTGGAGAAAATGTTGAAAGCTTTAAAATTAAATTCCAATGAA GCCAGATTGAAGTTTCCTAGATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTG AGCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAGCTGGATCAGC CACATGGTGGCCTTACTGGACAAAGACCAAGCCGTTGCTGTTCAGCACTCTGTGGAAGAA ATCACTGATAACTACCCGCAGGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTAT TCCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAGGATTAAAAGT AAGTTGGATCAAGGAGGAGTGATTCAAGATTTTATTAATGCCTTAGATCAGCTCTCTAAT CCTGAACTGCTCTTTAAGGATTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCT GTAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTTGGGTGACCCA AAGGCTCCAGGCCTGGGGGCCTTTAGAAGGAAGTTTATTCAGACTTTTGGAAAAGAATTT GATAAACATTTTGGGAAAGGAGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAAC GACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCCTGGGAATCTG AAAGAATGTTCACCCTGGATGAGCGACTTCAAAGTGGAGTTCCTGAGAAATGAGCTGGAG ATTCCCGGTCAGTATGACGGTAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCC GGGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCGCATCATCATC CGTGGCCATGACGAGAGGGAACACCCTTTCCTGGTGAAGGGTGGCGAGGACCTGCGGCAG GACCAGCGCGTGGAGCAGCTCTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCC TGCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGACCTCCAGTGAT CCCAGGGCACCGCCGTGTGAATATAAAGATTGGCTGACAAAAATGTCAGGAAAACATGAT GTTGGAGCTTACATGCTAATGTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTTTT AGAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTTCGTGAGGATGAGT ACAAGCCCTGAGGCTTTCCTGGCGCTCCGCTCCCACTTCGCCAGCTCTCACGCTCTGATA TGCATCAGCCACTGGATCCTCGGGATTGGAGACAGACATCTGAACAACTTTATGGTGGCC ATGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGGATCCGCTACACAG TTTCTGCCAGTCCCTGAGTTGATGCCTTTTCGGCTAACTCGCCAGTTTATCAATCTGATG TTACCAATGAAAGAAACGGGCCTTATGTACAGCATCATGGTACACGCACTCCGGGCCTTC CGCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAAGGAGCCCTCCTTT GATTGGAAAAATTTTGAACAGAAAATGCTGAAAAAAGGAGGGTCATGGATTCAAGAAATA AATGTTGCTGAAAAAAATTGGTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGTTA GCAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGGTCATGAGAAGGCC CCTGCCTTCAGAGACTATGTGGCTGTGGCACGAGGAAGCAAAGATCACAACATTCGTGCC CAAGAACCAGAGAGTGGGCTTTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGGCA ACAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTGGATGTGA
- Chromosome Location
- 8
- Locus
- 8q11.21
- External Identifiers
Resource Link UniProtKB ID P78527 UniProtKB Entry Name PRKDC_HUMAN GenBank Gene ID U47077 GeneCard ID PRKDC GenAtlas ID PRKDC HGNC ID HGNC:9413 PDB ID(s) 5LUQ, 5W1R, 5Y3R, 6ZFP, 6ZH2, 6ZH4, 6ZH6, 6ZH8, 6ZHA, 6ZHE, 7K0Y, 7K10, 7K11, 7K19, 7K1B, 7K1J, 7K1K, 7K1N, 7LT3, 7NFC, 7NFE, 7OTM, 7OTP, 7OTV, 7OTW, 7OTY, 7SGL, 7SU3, 7SUD, 7TYR, 7Z87, 7Z88, 8BH3, 8BHV, 8BHY, 8BOT, 8EZ9, 8EZA, 8EZB KEGG ID hsa:5591 IUPHAR/Guide To Pharmacology ID 2800 NCBI Gene ID 5591 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details SF1126 investigational unknown target Details Caffeine approved unknown target inhibitor Details PIK-75 investigational yes target inhibitor Details PP-121 experimental yes target inhibitor Details alpha-Naphthoflavone experimental yes target inhibitor Details Nedisertib investigational yes target inhibitor Details AZD-7648 investigational yes target inhibitor Details