Voltage-dependent calcium channel subunit alpha-2/delta-2

BE0002396ProteinHumansCACNA2D2

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. It is acted on by 9 drugs in DrugBank.

Gene name
CACNA2D2
UniProtKB entry
Q9NY47Swiss-Prot
Cellular location
Membrane
Residues / weight
1,150 residues · 129,816 Da
Also known as
KIAA0558 · Voltage-gated calcium channel subunit alpha-2/delta-2

Resolves to

Protein
UniProtQ9NY47UniProt nameCA2D2_HUMAN
Gene
HGNCHGNC:1400NCBI Gene9254GeneCardsCACNA2D2
Pharmacology
KEGGhsa:9254
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent calcium channel subunit alpha-2/delta-2, how selective are they, and which programs against it are still in active trials?

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