Disintegrin and metalloproteinase domain-containing protein 10

BE0002404ProteinHumansADAM10

Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032,... It is acted on by 2 drugs in DrugBank.

Gene name
ADAM10
UniProtKB entry
O14672Swiss-Prot
Cellular location
Cell membrane
Residues / weight
748 residues · 84,142 Da
Also known as
3.4.24.81 · ADAM 10 · CDw156 · KUZ · Kuzbanian protein homolog

Resolves to

Protein
UniProtO14672UniProt nameADA10_HUMAN
Gene
HGNCHGNC:188NCBI Gene102GeneCardsADAM10
Pharmacology
IUPHAR/GtoPdb1658KEGGhsa:102
Structure
PDB6BDZPDB6BE6PDB8ESV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Disintegrin and metalloproteinase domain-containing protein 10, and which indications are they being tested in?

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