XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically... XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied metalloprotease inhibitors.
- Mechanism
- Curator reviewed
XL784 is a potent small molecule inhibitor of the ADAM-10 metalloprotease enzyme, which plays a role in blood vessel formation and cell proliferation that can cause renal fibrosis and impairment.
- Primary indication
- For treatment in patients with diabetes who have clinically significant proteinuria.Curator reviewed
- Code names
- XL784
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with XL784, and which of those have an active Phase 3 trial?
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