Alpha-galactosidase A

BE0002422ProteinHumansGLA

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome. It is acted on by 9 drugs in DrugBank.

Gene name
GLA
UniProtKB entry
P06280Swiss-Prot
Cellular location
Lysosome
Residues / weight
429 residues · 48,766 Da
Also known as
3.2.1.22 · Alpha-D-galactosidase A · Alpha-D-galactoside galactohydrolase · Galactosylgalactosylglucosylceramidase GLA · Melibiase

Resolves to

Protein
UniProtP06280UniProt nameAGAL_HUMAN
Gene
HGNCHGNC:4296NCBI Gene2717GeneCardsGLA
Pharmacology
KEGGhsa:2717
Structure
PDB1R46PDB1R47PDB3GXN
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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15Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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73+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-galactosidase A, how selective are they, and which programs against it are still in active trials?

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