Sphingosine 1-phosphate receptor 5

BE0002432ProteinHumansS1PR5

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). It is acted on by 5 drugs in DrugBank.

Gene name
S1PR5
UniProtKB entry
Q9H228Swiss-Prot
Cellular location
Cell membrane
Residues / weight
398 residues · 41,775 Da
Also known as
EDG8 · Endothelial differentiation G protein-coupled receptor 8 · S1P receptor 5 · S1P receptor Edg-8 · S1P5

Resolves to

Protein
UniProtQ9H228UniProt nameS1PR5_HUMAN
Gene
HGNCHGNC:14299NCBI Gene53637GeneCardsS1PR5
Pharmacology
IUPHAR/GtoPdb279KEGGhsa:53637
Structure
PDB7EW1PDB7YXA
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine 1-phosphate receptor 5, how selective are they, and which programs against it are still in active trials?

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