Mucin-16

BE0002439ProteinHumansMUC16

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. It is acted on by 6 drugs in DrugBank.

Gene name
MUC16
UniProtKB entry
Q8WXI7Swiss-Prot
Cellular location
Cell membrane
Residues / weight
14,507 residues · 1,519,158 Da
Also known as
CA-125 · CA125 · MUC-16 · Ovarian cancer-related tumor marker CA125 · Ovarian carcinoma antigen CA125

Resolves to

Protein
UniProtQ8WXI7UniProt nameMUC16_HUMAN
Gene
HGNCHGNC:15582NCBI Gene94025GeneCardsMUC16
Pharmacology
KEGGhsa:94025
Structure
PDB7SA9PDB8GKLPDB8VM1
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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51Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mucin-16, how selective are they, and which programs against it are still in active trials?

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