Squalene synthase

BE0002444ProteinHumansFDFT1

Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. It is acted on by 4 drugs in DrugBank.

Gene name
FDFT1
UniProtKB entry
P37268Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
417 residues · 48,115 Da
Also known as
2.5.1.21 · Farnesyl-diphosphate farnesyltransferase · Farnesyl-diphosphate farnesyltransferase 1 · FPP:FPP farnesyltransferase · SQS

Resolves to

Protein
UniProtP37268UniProt nameFDFT_HUMAN
Gene
HGNCHGNC:3629NCBI Gene2222GeneCardsFDFT1
Pharmacology
IUPHAR/GtoPdb645KEGGhsa:2222
Structure
PDB1EZFPDB3ASXPDB3LEE
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Squalene synthase, how selective are they, and which programs against it are still in active trials?

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