E3 ubiquitin-protein ligase UBR4

BE0002460ProteinHumansUBR4

E3 ubiquitin-protein ligase involved in different protein quality control pathways in the cytoplasm (PubMed:25582440, PubMed:29033132, PubMed:34893540, PubMed:37891180, PubMed:38030679, PubMed:38182926, PubMed:38297121). It is acted on by 2 drugs in DrugBank.

Gene name
UBR4
UniProtKB entry
Q5T4S7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
5,183 residues · 573,835 Da
Also known as
2.3.2.27 · 600 kDa retinoblastoma protein-associated factor · KIAA0462 · KIAA1307 · N-recognin-4

Resolves to

Protein
UniProtQ5T4S7UniProt nameUBR4_HUMAN
Gene
HGNCHGNC:30313NCBI Gene23352GeneCardsUBR4
Pharmacology
KEGGhsa:23352
Structure
PDB8B5WPDB8BTLPDB8J9Q
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which compounds in development act on E3 ubiquitin-protein ligase UBR4, and which indications are they being tested in?

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