Picolinic acid

DB05483ExperimentalSmall molecule

PCL-016 or Picolinic acid drug substance is a pyridine carboxylate metabolite of tryptophan. It acts as an anti-infective and immunomodulator and is produced in approximately 25-50 mg quantities by the... PCL-016 plays a key role in zinc transport.

Mechanism: As a therapeutic agent, the molecule works by binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function.
Curator reviewed
Primary indication: Investigated for use/treatment in acne, herpes labialis infections (cold sores), and venereal disease.Curator reviewed
Formula / weight: C₆H₅NO₂ · 123.111 g/mol (avg)
Code names: PCL-016

Resolves to

Compound

UNIIQZV2W997JQCAS98-98-6ChEMBLCHEMBL72628ChEBI28747KEGGC10164

Clinical / RWD

RxNorm33684

Structure

InChIKeySIOXPEMLGUPBBT-UHFFFAOYSA-NSMILESOC(=O)C1=CC=CC=N1

Targets

Q5T4S7UBR4P08048ZFY

What you can answer from here — as of March 06, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Picolinic acid, and which of those have an active Phase 3 trial?

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