Myo-inositol hexaphosphate phosphohydrolase
Details
- Name
- Myo-inositol hexaphosphate phosphohydrolase
- Kind
- protein
- Synonyms
- Myo-inositol hexaphosphate phosphohydrolase precursor
- Gene Name
- phyA
- UniProtKB Entry
- Q7WUJ1TrEMBL
- Organism
- Selenomonas ruminantium
- NCBI Taxonomy ID
- 971
- Amino acid sequence
>lcl|BSEQ0019299|Myo-inositol hexaphosphate phosphohydrolase MKYWQKHAVLCSLLVGASLWILPQADAAKAPEQTVTEPVGSYARAERPQDFEGFVWRLDN DGKEALPRNFRTSADALRAPEKKFHLDAAYVPSREGMDALHISGSSAFTPAQLKNVAAKL REKTAGPIYDVDLRQESHGYLDGIPVSWYGERDWANLGKSQHEALADERHRLHAALHKTV YIAPLGKHKLPEGGEVRRVQKVQTEQEVAEAAGMRYFRIAATDHVWPTPENIDRFLAFYR TLPQDAWLHFHCEAGVGRTTAFMVMTDMLKNPSVSLKDILYRQHEIGGFYYGEFPIKTKD KDSWKTKYYREKIVMIEQFYRYVQENRADGYQTPWSVWLKSHPAKA
- Number of residues
- 346
- Molecular Weight
- 39651.705
- Theoretical pI
- 8.82
- GO Classification
- Functionsprotein tyrosine phosphatase activity
- General Function
- Not Available
- Specific Function
- hydrolase activity
- Pfam Domain Function
- Not Available
- Signal Regions
- 1-27
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0004902|1041 bp ATGAAATACTGGCAGAAGCATGCCGTTCTTTGTAGTCTCTTGGTCGGCGCATCCCTCTGG ATACTGCCGCAGGCCGATGCGGCCAAGGCGCCGGAGCAGACGGTGACGGAGCCCGTTGGG AGCTACGCGCGCGCGGAGCGGCCGCAGGACTTCGAGGGCTTTGTCTGGCGCCTCGACAAC GACGGCAAGGAGGCGTTGCCACGTAATTTCCGCACGTCGGCTGACGCGCTGCGCGCGCCG GAGAAGAAATTCCATCTCGACGCCGCGTATGTACCGTCGCGCGAGGGCATGGATGCACTC CATATCTCGGGCAGTTCCGCATTCACGCCGGCGCAGCTCAAGAACGTTGCCGCGAAGCTG CGGGAGAAGACGGCTGGCCCCATCTACGATGTCGACCTACGGCAGGAGTCGCACGGCTAT CTCGACGGTATCCCCGTGAGCTGGTACGGCGAGCGCGACTGGGCAAATCTCGGCAAGAGC CAGCATGAGGCGCTCGCCGACGAGCGGCACCGCTTGCACGCAGCGCTCCATAAGACGGTC TACATCGCGCCGCTCGGCAAGCACAAGCTCCCCGAGGGCGGCGAAGTCCGCCGCGTACAG AAGGTGCAGACGGAACAGGAAGTCGCCGAGGCCGCGGGGATGCGCTATTTCCGCATCGCG GCGACGGATCATGTCTGGCCAACGCCGGAGAACATCGACCGCTTCCTCGCGTTTTACCGC ACGCTGCCGCAGGATGCGTGGCTCCATTTCCATTGTGAAGCCGGTGTCGGCCGCACGACG GCGTTCATGGTCATGACGGATATGCTGAAGAACCCGTCCGTATCGCTCAAGGACATCCTC TATCGCCAGCACGAGATCGGCGGCTTTTACTACGGGGAGTTCCCCATCAAGACGAAGGAT AAAGATAGCTGGAAGACGAAATATTATAGGGAAAAGATCGTGATGATCGAGCAGTTCTAC CGCTATGTGCAGGAGAACCGCGCGGATGGCTACCAGACGCCGTGGTCGGTCTGGCTCAAG AGCCATCCGGCGAAGGCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q7WUJ1 UniProtKB Entry Name Q7WUJ1_SELRU GenBank Gene ID AF177214 PDB ID(s) 1U24, 1U25, 1U26, 2B4O, 2B4P, 2B4U, 2PSZ, 2PT0, 3D1H, 3D1O, 3D1Q, 3MMJ, 3MOZ, 3O3L, 4WTY, 4WU2 - General References
- Chu HM, Guo RT, Lin TW, Chou CC, Shr HL, Lai HL, Tang TY, Cheng KJ, Selinger BL, Wang AH: Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis. Structure. 2004 Nov;12(11):2015-24. [Article]
- Puhl AA, Gruninger RJ, Greiner R, Janzen TW, Mosimann SC, Selinger LB: Kinetic and structural analysis of a bacterial protein tyrosine phosphatase-like myo-inositol polyphosphatase. Protein Sci. 2007 Jul;16(7):1368-78. Epub 2007 Jun 13. [Article]
- Gruninger RJ, Selinger LB, Mosimann SC: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr. FEBS J. 2008 Aug;275(15):3783-92. doi: 10.1111/j.1742-4658.2008.06524.x. [Article]
- Gruninger RJ, Dobing S, Smith AD, Bruder LM, Selinger LB, Wieden HJ, Mosimann SC: Substrate binding in protein-tyrosine phosphatase-like inositol polyphosphatases. J Biol Chem. 2012 Mar 23;287(13):9722-30. doi: 10.1074/jbc.M111.309872. Epub 2011 Dec 2. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-Myo-Inositol-Hexasulphate experimental unknown target Details