rRNA adenine N-6-methyltransferase

BE0002516ProteinBacillus subtilisermC'

This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics. It is acted on by 2 drugs in DrugBank.

Gene name
ermC'
UniProtKB entry
P13956Swiss-Prot
Residues / weight
244 residues · 28,907 Da
Also known as
2.1.1.184 · Erythromycin resistance protein · Macrolide-lincosamide-streptogramin B resistance protein

Resolves to

Protein
UniProtP13956UniProt nameERM_BACIU
Gene
NCBI Gene1263203
Pharmacology
KEGGpg:1263203
Structure
PDB1QAMPDB1QANPDB1QAO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on rRNA adenine N-6-methyltransferase, and which indications are they being tested in?

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