Siroheme synthase

BE0002522ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)cysG

Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. It is acted on by 2 drugs in DrugBank.

Gene name
cysG
UniProtKB entry
P25924Swiss-Prot
Residues / weight
457 residues · 50,146 Da
Also known as
2.1.1.107 · Urogen III methylase

Resolves to

Protein
UniProtP25924UniProt nameCYSG_SALTY
Gene
NCBI Gene1255000
Pharmacology
KEGGstm:STM3477
Structure
PDB1PJQPDB1PJSPDB1PJT
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Siroheme synthase, and which indications are they being tested in?

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