Aclacinomycin 10-hydroxylase RdmB

BE0002526ProteinStreptomyces purpurascensrdmB

Involved in the biosynthesis of the anthracycline aclacinomycin which is an aromatic polyketide antibiotic that exhibits high cytotoxicity and is widely applied in the chemotherapy of a variety of cancers. It is acted on by 3 drugs in DrugBank.

Gene name
rdmB
UniProtKB entry
Q54527Swiss-Prot
Residues / weight
374 residues · 39,797 Da
Also known as
15-demethoxy-epsilon-rhodomycin 10-hydroxylase · 15-demethoxyaclacinomycin T · 4.1.1.- · SAM-dependent methyltransferase RdmB

Resolves to

Protein
UniProtQ54527UniProt nameRDMB_STREF
Pharmacology
KEGGag:AAA83421
Structure
PDB1QZZPDB1R00PDB1XDS
Drugs

What you can answer from here — as of September 04, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Aclacinomycin 10-hydroxylase RdmB, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In