Type II methyltransferase M.TaqI

BE0002531ProteinThermus aquaticustaqIM

A gamma subtype methylase that recognizes the double-stranded sequence 5'-TCGA-3', methylates A-4 on both strands and protects the DNA from cleavage by the TaqI endonuclease. It is acted on by 2 drugs in DrugBank.

Gene name
taqIM
UniProtKB entry
P14385Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
421 residues · 47,862 Da
Also known as
2.1.1.72 · Adenine-specific methyltransferase TaqI · M.TaqI · Modification methylase TaqI

Resolves to

Protein
UniProtP14385UniProt nameMTTA_THEAQ
Structure
PDB1AQIPDB1AQJPDB1G38
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type II methyltransferase M.TaqI, and which indications are they being tested in?

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