Aminoglycoside 2'-N-acetyltransferase

BE0002566ProteinMycobacterium tuberculosisaac

May catalyze the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides and confer resistance to aminoglycosides (By similarity). It is acted on by 4 drugs in DrugBank.

Gene name
aac
UniProtKB entry
P9WQG9Swiss-Prot
Residues / weight
181 residues · 20,038 Da
Also known as
2.3.1.- · AAC(2')-Ic

Resolves to

Protein
UniProtP9WQG9UniProt nameAAC2_MYCTU
Gene
NCBI Gene886648
Pharmacology
KEGGag:AAB17563
Structure
PDB1M44PDB1M4DPDB1M4G
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminoglycoside 2'-N-acetyltransferase, how selective are they, and which programs against it are still in active trials?

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