dTDP-glucose 4,6-dehydratase

Details

Name
dTDP-glucose 4,6-dehydratase
Kind
protein
Synonyms
  • 4.2.1.46
Gene Name
rmlB
UniProtKB Entry
P95780Swiss-Prot
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
NCBI Taxonomy ID
210007
Amino acid sequence
>lcl|BSEQ0016843|dTDP-glucose 4,6-dehydratase
MTEYKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNRANLEEILGDRVELVV
GDIADSELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYILLEAARKYDIRF
HHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFG
VKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVWAI
LTKGRIGETYLIGADGEKNNKEVLELILEKMSQPKNAYDHVTDRAGHDLRYAIDSTKLRE
ELGWKPQFTNFEEGLEDTIKWYTEHEDWWKAEKEAVEANYAKTQKILN
Number of residues
348
Molecular Weight
39280.625
Theoretical pI
5.73
GO Classification
Functions
dTDP-glucose 4,6-dehydratase activity
Processes
dTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process
General Function
Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
Specific Function
dTDP-glucose 4,6-dehydratase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016844|dTDP-glucose 4,6-dehydratase (rmlB)
ATGACAGAATATAAAAACATTATCGTTACCGGTGGCGCTGGTTTCATCGGTTCAAACTTT
GTCCACTACGTTTACAATAATCACCCAGATGTCCATGTGACTGTTCTTGACAAACTCACT
TACGCTGGTAACCGTGCTAACCTTGAAGAAATTCTTGGCGACCGTGTAGAGTTGGTTGTT
GGGGACATCGCAGACAGCGAATTGGTAGATAAATTGGCTGCCAAAGCGGATGCTATTGTC
CACTATGCGGCTGAAAGCCACAATGACAATTCACTAAAAGATCCATCACCATTTATTTAC
ACTAACTTTGTTGGAACTTATATCTTGTTGGAAGCTGCACGCAAATACGACATCCGTTTC
CACCACGTCTCAACTGATGAAGTTTACGGTGATCTTCCGCTACGTGAAGATTTGCCGGGC
CACGGTGAAGGTCCAGGTGAAAAATTCACAGCTGAAACGAAATACAATCCATCATCGCCT
TATTCATCAACCAAGGCAGCCTCTGACTTGATTGTCAAGGCTTGGGTGCGATCTTTTGGT
GTGAAAGCAACCATTTCCAACTGTTCAAACAACTATGGACCTTACCAACACATCGAAAAA
TTCATTCCGCGCCAAATTACTAACATCCTGTCAGGTATCAAACCAAAACTCTATGGTGAA
GGTAAGAACGTGCGTGACTGGATTCACACCAATGACCATTCAACAGGAGTTTGGGCAATT
CTCACTAAAGGCCGCATCGGCGAAACTTATCTCATCGGTGCTGATGGTGAAAAGAACAAC
AAAGAAGTGCTCGAACTTATCCTTGAAAAAATGAGTCAGCCAAAAAATGCATACGACCAT
GTAACAGACCGTGCAGGTCATGATCTTCGTTATGCCATTGATTCGACAAAGCTGCGTGAA
GAGCTTGGCTGGAAACCACAATTCACTAATTTTGAAGAAGGCTTGGAAGATACCATTAAA
TGGTATACTGAGCATGAAGATTGGTGGAAAGCTGAAAAGGAAGCAGTCGAAGCCAACTAT
GCCAAAACACAAAAAATACTTAATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP95780
UniProtKB Entry NameRMLB_STRMU
GenBank Gene IDD78182
PDB ID(s)1KEP, 1KET
KEGG IDsmu:SMU_1457
NCBI Gene ID1028708
General References
  1. Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ: Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. Epub 2002 Oct 23. [Article]
  2. Allard ST, Beis K, Giraud MF, Hegeman AD, Gross JW, Wilmouth RC, Whitfield C, Graninger M, Messner P, Allen AG, Maskell DJ, Naismith JH: Toward a structural understanding of the dehydratase mechanism. Structure. 2002 Jan;10(1):81-92. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Thymidine-5'-diphospho-beta-D-xyloseexperimentalunknowntargetDetails
2'deoxy-Thymidine-5'-Diphospho-Alpha-D-GlucoseexperimentalunknowntargetDetails