dTDP-glucose 4,6-dehydratase

BE0002627ProteinStreptococcus mutans serotype c (strain ATCC 700610 / UA159)rmlB

Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. It is acted on by 2 drugs in DrugBank.

Gene name
rmlB
UniProtKB entry
P95780Swiss-Prot
Residues / weight
348 residues · 39,281 Da
Also known as
4.2.1.46

Resolves to

Protein
UniProtP95780UniProt nameRMLB_STRMU
Gene
NCBI Gene1028708
Pharmacology
KEGGsmu:SMU_1457
Structure
PDB1KEPPDB1KET
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on dTDP-glucose 4,6-dehydratase, and which indications are they being tested in?

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