Aminoglycoside N(6')-acetyltransferase type 1

BE0002677ProteinSalmonella enteritidis

Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. It is acted on by 3 drugs in DrugBank.

UniProtKB entry
Q9R381Swiss-Prot
Residues / weight
145 residues · 16,361 Da
Also known as
2.3.1.82 · AAC(6')-Iy · Aminoglycoside resistance protein

Resolves to

Protein
UniProtQ9R381UniProt nameAAC6_SALEN
Pharmacology
KEGGag:AAF03531
Structure
PDB1S3ZPDB1S5KPDB1S60
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aminoglycoside N(6')-acetyltransferase type 1, how selective are they, and which programs against it are still in active trials?

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