CCA-adding enzyme

BE0002744ProteinGeobacillus stearothermophiluscca

Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. It is acted on by 1 drug in DrugBank.

Gene name
cca
UniProtKB entry
Q7SIB1Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
404 residues · 45,369 Da
Also known as
2.7.7.72 · CCA tRNA nucleotidyltransferase · tRNA adenylyl-/cytidylyl- transferase · tRNA CCA-pyrophosphorylase · tRNA nucleotidyltransferase

Resolves to

Protein
UniProtQ7SIB1UniProt nameCCA_GEOSE
Structure
PDB1MIVPDB1MIWPDB1MIY
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on CCA-adding enzyme, and which indications are they being tested in?

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