Envelope glycoprotein gp160
Details
- Name
- Envelope glycoprotein gp160
- Kind
- protein
- Synonyms
- Env polyprotein
- Gene Name
- env
- UniProtKB Entry
- P12488Swiss-Prot
- Organism
- HIV-1
- NCBI Taxonomy ID
- 11693
- Amino acid sequence
>lcl|BSEQ0011997|Envelope glycoprotein gp160 MRVKGIKKNYQHLWRWGGMMLLGILMICSATDKLWVTVYYGVPVWKEANTTLFCASDAKA YDTEIHNVWATHACVPTDPNPQELVMGNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCV KLTPLCVTLNCHDFNATNATSNSGKMMEGGEMKNCSFNITTSIRDKMQKEYALFYKLDIV PIDNDKTNTRYRLISCNTSVITQACPKVTFEPIPIHYCAPAGFAILKCNNKKFNGTGPCT NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTNNVKTIIVQLNESVEINCTRPN NNTRKRITMGPGRVYYTTGQIIGDIRRAHCNLSRSKWENTLKQIVTKLRVQFKNKTIVFN RSSGGDPEIVMHSFNCGGEFFFCNTTQLFNSTWYRNTTGNITEGNSPITLPCRIKQIINM WQEVGKAMYAPPIRGQIKCSSNITGLLLTRDGGNNNETTDTEIFRPGGGNMRDNWRSELY KYKVVKIEPLGVAPTKAKRRVVQREKRAVGLGALFLGFLGAAGSTMGAASLTLTVQARLL LSGIVQQQNNLLMAIEAQQHMLELTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLIC TTAVPWNASWSNKSLSDIWDNMTWMEWEREIDNYTNLIYSLIEDSQIQQEKNEKELLELD KWASLWNWFNITNWLWYIKIFIMIVGGLIGLRIVFAVLSIVNRVRQGYSPLSFQTRLPGR RGPDRPEGIEEEGGERDRDRSSPLVDGFLALFWVDLRSLFLFSYHRLRDLLLIVTRIVEL LGRRGWEVLKYWWNLLQYWSQELKNSAVSLLNATAIAVGERTDRAIEVVQRAFRAILHIP RRIRQGLERALQ
- Number of residues
- 852
- Molecular Weight
- 97202.505
- Theoretical pI
- 9.21
- GO Classification
- Functionsstructural molecule activityProcessesapoptotic process / clathrin-mediated endocytosis of virus by host cell / evasion or tolerance by virus of host immune response / fusion of virus membrane with host endosome membrane / fusion of virus membrane with host plasma membrane / innate immune response / stimulatory C-type lectin receptor signaling pathway / viral protein processing / virion attachment to host cellComponentshost cell endosome membrane / host cell plasma membrane / integral component of membrane / viral envelope / virion / virion membrane
- General Function
- Envelope glycoprotein gp160 Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
- Specific Function
- structural molecule activity
- Pfam Domain Function
- Signal Regions
- 1-30
- Transmembrane Regions
- 681-701
- Cellular Location
- Virion membrane
- Gene sequence
>lcl|BSEQ0005556|2559 bp ATGAGAGTGAAGGGGATCAAGAAGAATTATCAGCACTTGTGGAGATGGGGGGGCATGATG CTCCTTGGGATATTGATGATCTGTAGTGCTACAGACAAATTGTGGGTCACAGTCTATTAT GGGGTACCTGTGTGGAAAGAAGCAAACACCACTCTATTTTGTGCATCAGATGCTAAAGCA TATGATACAGAGATACATAATGTCTGGGCCACACATGCCTGTGTACCCACAGACCCCAAC CCACAAGAATTAGTAATGGGAAATGTGACAGAAAATTTTAACATGTGGAAAAATGACATG GTAGAACAGATGCATGAGGATATAATCAGTTTATGGGATCAAAGCCTAAAGCCATGTGTA AAATTAACCCCACTCTGTGTTACTTTAAATTGCCATGATTTCAATGCTACTAATGCCACT AGTAATAGCGGGAAAATGATGGAGGGAGGAGAAATGAAAAACTGCTCTTTCAATATCACC ACAAGCATAAGAGATAAGATGCAGAAAGAATATGCACTTTTTTATAAACTTGATATAGTA CCAATAGATAATGATAAAACTAATACTAGATATAGGTTGATAAGTTGTAATACCTCAGTC ATTACACAGGCCTGTCCAAAGGTAACCTTTGAGCCAATTCCCATACATTATTGTGCCCCG GCTGGTTTTGCGATTCTAAAGTGTAATAATAAGAAGTTCAATGGAACAGGACCATGTACA AATGTCAGCACAGTACAATGTACACATGGAATTAGGCCAGTAGTATCCACTCAATTGCTG TTAAATGGCAGTCTAGCAGAAGAAGAGGTAGTAATTAGATCTGAAAATTTCACGAACAAT GTTAAAACCATAATAGTACAGCTGAATGAATCTGTAGAAATTAATTGTACAAGACCCAAC AACAATACAAGAAAGAGGATAACTATGGGACCAGGGAGAGTATATTATACAACAGGACAA ATAATAGGAGATATAAGACGAGCACATTGTAACCTTAGTAGATCAAAATGGGAGAACACT TTAAAACAGATAGTTACAAAATTAAGAGTACAATTTAAGAATAAAACAATAGTCTTTAAT CGATCCTCAGGAGGGGACCCAGAAATTGTAATGCACAGTTTTAATTGTGGAGGGGAATTT TTCTTCTGTAATACAACACAACTGTTTAATAGTACTTGGTATAGGAACACTACAGGAAAT ATCACTGAAGGAAATAGCCCAATCACACTCCCATGCAGAATAAAACAAATTATAAACATG TGGCAGGAAGTAGGAAAAGCAATGTATGCCCCTCCCATCAGAGGACAAATTAAATGTTCA TCAAATATTACAGGGCTGCTATTAACAAGAGATGGTGGTAATAACAACGAGACCACCGAC ACCGAGATCTTCAGACCTGGAGGAGGAAATATGAGGGACAATTGGAGAAGTGAATTATAT AAATATAAAGTAGTAAAAATTGAACCATTAGGAGTAGCACCCACCAAGGCAAAGAGAAGA GTGGTGCAGAGAGAAAAAAGAGCAGTGGGACTAGGAGCTTTGTTCCTTGGGTTCTTAGGA GCAGCAGGAAGCACTATGGGCGCAGCGTCCCTGACGCTGACGGTACAGGCCAGACTATTA TTGTCTGGTATAGTGCAACAGCAGAACAACTTGCTGATGGCTATTGAGGCGCAACAGCAT ATGTTGGAACTTACAGTCTGGGGCATCAAGCAGCTCCAGGCAAGAGTCCTGGCTGTAGAA AGATACCTAAAGGACCAACAGCTCCTGGGGATTTGGGGTTGCTCTGGAAAACTCATTTGC ACCACTGCTGTGCCTTGGAATGCTAGTTGGAGTAATAAATCTCTGAGTGACATTTGGGAT AACATGACCTGGATGGAGTGGGAAAGAGAAATTGACAATTATACAAACTTAATATACTCC TTAATTGAGGACTCGCAAATCCAACAAGAAAAGAATGAAAAAGAATTATTAGAATTAGAC AAGTGGGCAAGTTTGTGGAATTGGTTCAACATAACAAACTGGCTGTGGTATATAAAAATA TTCATAATGATAGTAGGGGGCTTGATAGGTTTAAGAATAGTTTTTGCTGTACTTTCTATA GTGAATAGAGTTAGGCAGGGATACTCACCATTATCGTTTCAGACCCGCCTCCCAGGCCGG AGGGGACCCGACAGGCCCGAAGGAATCGAAGAAGAAGGTGGAGAGCGAGACAGAGACAGA TCCAGTCCCTTAGTGGATGGATTCTTAGCACTTTTCTGGGTCGATCTGCGGAGCCTGTTC CTCTTCAGCTACCACCGCTTGAGAGACTTACTCTTGATTGTAACGAGGATTGTGGAACTT CTGGGACGCAGGGGGTGGGAAGTCCTCAAATATTGGTGGAATCTCCTACAGTATTGGAGT CAGGAACTAAAGAATAGTGCTGTTAGCTTGCTCAACGCCACAGCCATAGCAGTAGGTGAG AGGACAGATAGGGCTATAGAAGTAGTACAAAGAGCTTTTAGAGCTATCCTGCACATACCT AGAAGAATAAGACAGGGCTTGGAAAGGGCTTTGCAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12488 UniProtKB Entry Name ENV_HV1BN GenBank Gene ID M21098 PDB ID(s) 1IM7, 1J8N, 1J8Z, 1J9V, 1JAA, 1JAR, 1JC8, 1JCP - General References
- Anand R, Thayer R, Srinivasan A, Nayyar S, Gardner M, Luciw P, Dandekar S: Biological and molecular characterization of human immunodeficiency virus (HIV-1BR) from the brain of a patient with progressive dementia. Virology. 1989 Jan;168(1):79-89. [Article]
- Geijtenbeek TB, van Kooyk Y: Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity. APMIS. 2003 Jul-Aug;111(7-8):698-714. [Article]
- Gallo SA, Finnegan CM, Viard M, Raviv Y, Dimitrov A, Rawat SS, Puri A, Durell S, Blumenthal R: The HIV Env-mediated fusion reaction. Biochim Biophys Acta. 2003 Jul 11;1614(1):36-50. [Article]
- Perfettini JL, Castedo M, Roumier T, Andreau K, Nardacci R, Piacentini M, Kroemer G: Mechanisms of apoptosis induction by the HIV-1 envelope. Cell Death Differ. 2005 Aug;12 Suppl 1:916-23. [Article]
- Hartley O, Klasse PJ, Sattentau QJ, Moore JP: V3: HIV's switch-hitter. AIDS Res Hum Retroviruses. 2005 Feb;21(2):171-89. [Article]
- Reeves JD, Piefer AJ: Emerging drug targets for antiretroviral therapy. Drugs. 2005;65(13):1747-66. [Article]
- Lusso P: HIV and the chemokine system: 10 years later. EMBO J. 2006 Feb 8;25(3):447-56. Epub 2006 Jan 26. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Beta-3-Cysteine experimental unknown target Details Beta-3-Serine experimental unknown target Details L-2,4-diaminobutyric acid experimental unknown target Details 3-Amino-Alanine experimental unknown target Details Fostemsavir approved, investigational yes target inhibitor Details