Focal adhesion kinase 1

BE0003090ProteinHumansPTK2

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. It is acted on by 15 drugs in DrugBank.

Gene name
PTK2
UniProtKB entry
Q05397Swiss-Prot
Cellular location
Cell junction, focal adhesion
Residues / weight
1,052 residues · 119,232 Da
Also known as
2.7.10.2 · FADK 1 · FAK · FAK1 · Focal adhesion kinase-related nonkinase

Resolves to

Protein
UniProtQ05397UniProt nameFAK1_HUMAN
Gene
HGNCHGNC:9611NCBI Gene5747GeneCardsPTK2
Pharmacology
IUPHAR/GtoPdb2180KEGGhsa:5747
Structure
PDB1K04PDB1K05PDB1MP8
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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8Clinical trialsTrials of drugs acting on it, by phase and status
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42GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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111+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Focal adhesion kinase 1, how selective are they, and which programs against it are still in active trials?

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