Endonuclease 8-like 1

BE0003175ProteinHumansNEIL1

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. It is acted on by 7 drugs in DrugBank.

Gene name
NEIL1
UniProtKB entry
Q96FI4Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
390 residues · 43,684 Da
Also known as
3.2.2.- · 4.2.99.18 · DNA glycosylase/AP lyase Neil1 · DNA-(apurinic or apyrimidinic site) lyase Neil1 · Endonuclease VIII-like 1

Resolves to

Protein
UniProtQ96FI4UniProt nameNEIL1_HUMAN
Gene
HGNCHGNC:18448NCBI Gene79661GeneCardsNEIL1
Pharmacology
KEGGhsa:79661
Structure
PDB1TDHPDB4NRVPDB5ITQ
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Endonuclease 8-like 1, how selective are they, and which programs against it are still in active trials?

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