Aminoimidazole riboside kinase

BE0003197ProteinSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

Phosphorylates 5-amino-1-(beta-D-ribosyl)imidazole (AIRs) to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the purine and thiamine biosynthetic pathways (PubMed:12486071). It is acted on by 2 drugs in DrugBank.

UniProtKB entry
Q8ZKR2TrEMBL
Residues / weight
319 residues · 34,237 Da
Also known as
2.7.1.223 · AIRs kinase · EC 2.7.1.4 · EC 3.6.1.26 · Putative sugar kinase

Resolves to

Protein
UniProtQ8ZKR2UniProt nameAIRSK_SALTY
Gene
NCBI Gene1255593
Pharmacology
KEGGstm:STM4066
Structure
PDB1TYYPDB1TZ3PDB1TZ6
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Aminoimidazole riboside kinase, and which indications are they being tested in?

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