L-methionine gamma-lyase

BE0003208ProteinPseudomonas putidamdeA

Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia (PubMed:6742420, PubMed:8586629). It is acted on by 4 drugs in DrugBank.

Gene name
mdeA
UniProtKB entry
P13254Swiss-Prot
Residues / weight
398 residues · 42,626 Da
Also known as
4.4.1.11 · Homocysteine desulfhydrase · L-methioninase · Methionine gamma-lyase · MGL

Resolves to

Protein
UniProtP13254UniProt nameMEGL_PSEPU
Structure
PDB1GC0PDB1GC2PDB1PG8
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on L-methionine gamma-lyase, how selective are they, and which programs against it are still in active trials?

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