GDP-mannose 4,6 dehydratase

BE0003278ProteinHumansGMDS

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. It is acted on by 3 drugs in DrugBank.

Gene name
GMDS
UniProtKB entry
O60547Swiss-Prot
Residues / weight
372 residues · 41,949 Da
Also known as
4.2.1.47 · GDP-D-mannose dehydratase · GMD

Resolves to

Protein
UniProtO60547UniProt nameGMDS_HUMAN
Gene
HGNCHGNC:4369NCBI Gene2762GeneCardsGMDS
Pharmacology
KEGGhsa:2762
Structure
PDB1T2APDB5IN4PDB5IN5
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on GDP-mannose 4,6 dehydratase, and which indications are they being tested in?

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