Ribonuclease pancreatic

BE0003317ProteinHumansRNASE1

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. It is acted on by 27 drugs in DrugBank.

Gene name
RNASE1
UniProtKB entry
P07998Swiss-Prot
Cellular location
Secreted
Residues / weight
156 residues · 17,644 Da
Also known as
4.6.1.18 · HP-RNase · RIB-1 · RIB1 · Ribonuclease 1

Resolves to

Protein
UniProtP07998UniProt nameRNAS1_HUMAN
Gene
HGNCHGNC:10044NCBI Gene6035GeneCardsRNASE1
Pharmacology
KEGGhsa:6035
Structure
PDB1DZAPDB1E21PDB1H8X
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribonuclease pancreatic, how selective are they, and which programs against it are still in active trials?

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