Aklanonic acid methyl ester cyclase AcmA

BE0003340ProteinStreptomyces galilaeusacma

Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). It is acted on by 1 drug in DrugBank.

Gene name
acma
UniProtKB entry
O52646Swiss-Prot
Residues / weight
144 residues · 16,731 Da
Also known as
5.5.1.23 · AAME cyclase · aknH · Methyl aklanonate cyclase

Resolves to

Protein
UniProtO52646UniProt nameDNRD_STRGJ
Pharmacology
KEGGag:AAF70112
Structure
PDB2F98PDB2F99
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aklanonic acid methyl ester cyclase AcmA, and which indications are they being tested in?

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