DNA-directed RNA polymerase subunit beta

BE0003367ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)rpoB

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 4 drugs in DrugBank.

Gene name
rpoB
UniProtKB entry
Q8RQE9Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
1,119 residues · 125,263 Da
Also known as
2.7.7.6 · RNA polymerase subunit beta · RNAP subunit beta · Transcriptase subunit beta

Resolves to

Protein
UniProtQ8RQE9UniProt nameRPOB_THET8
Gene
NCBI Gene3169736
Pharmacology
KEGGttj:TTHA1813
Structure
PDB1IW7PDB1SMYPDB1ZYR
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase subunit beta, and which indications are they being tested in?

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