DNA-directed RNA polymerase subunit beta'

BE0003368ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)rpoC

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 4 drugs in DrugBank.

Gene name
rpoC
UniProtKB entry
Q8RQE8Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
1,524 residues · 170,755 Da
Also known as
2.7.7.6 · RNA polymerase subunit beta' · RNAP subunit beta' · Transcriptase subunit beta'

Resolves to

Protein
UniProtQ8RQE8UniProt nameRPOC_THET8
Gene
NCBI Gene3169754
Pharmacology
KEGGttj:TTHA1812
Structure
PDB1IW7PDB1SMYPDB1ZYR
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase subunit beta', and which indications are they being tested in?

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