Angiopoietin-1 receptor

BE0003379ProteinHumansTEK

Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular... It is acted on by 15 drugs in DrugBank.

Gene name
TEK
UniProtKB entry
Q02763Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,124 residues · 125,829 Da
Also known as
2.7.10.1 · Endothelial tyrosine kinase · hTIE2 · p140 TEK · TIE2

Resolves to

Protein
UniProtQ02763UniProt nameTIE2_HUMAN
Gene
HGNCHGNC:11724NCBI Gene7010GeneCardsTEK
Pharmacology
IUPHAR/GtoPdb1842KEGGhsa:7010
Structure
PDB1FVRPDB2GY5PDB2GY7
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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68+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Angiopoietin-1 receptor, how selective are they, and which programs against it are still in active trials?

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