ESK981

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DB18155InvestigationalSmall molecule

ESK981: Overview.

Mechanism: Pharmacologically active on Vascular endothelial growth factor receptor and Angiopoietin-1 receptor
Curator reviewed
Formula / weight: C₃₅H₃₅N₇O₄S · 649.77 g/mol (avg)
Also known as: 4h-indazolo(5,4-a)pyrrolo(3,4-c)carbazol-4-one, 2,5,6,11,12,13-hexahydro-2-methyl-11-(2-methylpropyl)-8-(2-pyrimidinylamino)-, 4-methylbenzenesulfonate (1:1) · Bol 303213x tosylate · Bol-303213x tosylate · Cep-11981 tosylate
Code names: BOL-303213X · CEP-11981 · ESK-981

Resolves to

Compound

UNIIJ8AY0Z4CBPCAS856691-93-5

Structure

InChIKeyOCCDXAYTEKPNMM-UHFFFAOYSA-NSMILESCC1=CC=C(C=C1)S(O)(=O)=O.CC(C)CN1C2=C(C=C(NC3=NC=CC=N3)C=C2)C2=C1C1=C(C3=CN(C)N=C3CC1)C1=C2CNC1=O

Targets

Q02763TEKP35968KDRP17948FLT1

What you can answer from here — as of September 12, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with ESK981, and which of those have an active Phase 3 trial?

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