Serine/threonine-protein kinase Chk2

BE0003381ProteinHumansCHEK2

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. It is acted on by 7 drugs in DrugBank.

Gene name
CHEK2
UniProtKB entry
O96017Swiss-Prot
Cellular location
Nucleus
Residues / weight
543 residues · 60,914 Da
Also known as
2.7.11.1 · CDS1 · Cds1 homolog · Checkpoint kinase 2 · CHK2

Resolves to

Protein
UniProtO96017UniProt nameCHK2_HUMAN
Gene
HGNCHGNC:16627NCBI Gene11200GeneCardsCHEK2
Pharmacology
IUPHAR/GtoPdb1988KEGGhsa:11200
Structure
PDB1GXCPDB2CN5PDB2CN8
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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72+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase Chk2, how selective are they, and which programs against it are still in active trials?

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