Cytochrome c oxidase subunit 2

BE0003385ProteinHumansMT-CO2

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. It is acted on by 3 drugs in DrugBank.

Gene name
MT-CO2
UniProtKB entry
P00403Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
227 residues · 25,565 Da
Also known as
7.1.1.9 · COII · COX2 · COXII · Cytochrome c oxidase polypeptide II

Resolves to

Protein
UniProtP00403UniProt nameCOX2_HUMAN
Gene
HGNCHGNC:7421NCBI Gene4513GeneCardsMT-CO2
Pharmacology
KEGGhsa:4513
Structure
PDB3VRJPDB5Z62PDB9I6F
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome c oxidase subunit 2, how selective are they, and which programs against it are still in active trials?

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