Mitogen-activated protein kinase 11

BE0003390ProteinHumansMAPK11

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). It is acted on by 7 drugs in DrugBank.

Gene name
MAPK11
UniProtKB entry
Q15759Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
364 residues · 41,357 Da
Also known as
2.7.11.24 · MAP kinase 11 · MAP kinase p38 beta · MAPK 11 · Mitogen-activated protein kinase p38 beta

Resolves to

Protein
UniProtQ15759UniProt nameMK11_HUMAN
Gene
HGNCHGNC:6873NCBI Gene5600GeneCardsMAPK11
Pharmacology
IUPHAR/GtoPdb1500KEGGhsa:5600
Structure
PDB3GC8PDB3GC9PDB3GP0
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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34+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitogen-activated protein kinase 11, how selective are they, and which programs against it are still in active trials?

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